Journal article
Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial.
undefined SUNRRISE Trial Study Group, Kristy Atherton, James Brown, Hamish Clouston, Pete Coe, Rui Duarte, Nagendra N Dudi-Venkata, Sarah Duff, Natasha Egoroff, Rebecca Fish, James Glasbey, Natalie Ives, Manjinder Kaur, Laura Magill, Samir Mehta, Thomas Pinkney, Peter Pockney, Toby Richards, Tarik Sammour, Hema Sekhar Show all
JAMA | Published : 2025
Abstract
IMPORTANCE: Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting. OBJECTIVE: To evaluate the effectiveness of iNPWT in reducing the rate of SSI in adults undergoing emergency laparotomy with primary skin closure. DESIGN, SETTING, AND PARTICIPANTS: SUNRRISE was an assessor-masked, pragmatic, phase 3, individual-participant, randomized clinical trial. Adult patients undergoing emergency laparotomy in 22 hospitals in the UK and 12 hospitals in Australia between December 18, 2018, and May 25, 2021, were recruited. Patients were ..
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