Journal article

Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder

L Webb, LJ Hearne, YE Tian, A Zalesky, C Robinson, CV Hall, S Sonkusare, B Burgher, M Breakspear, GM Meyer, A Horn, S Naze, P Mosley, L Cocchi

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | Elsevier | Published : 2025

DOI: 10.1016/j.bpsc.2025.07.006

Abstract

Background Obsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge gap. These gradients provide a spatial representation of continuous changes in whole-brain connectivity within striatal regions. Thus, OCD-related differences in striatal gradients imply changes in the functional organization of striatal connections. Methods We calculated spatial striatal gradients linked to whole-brain activity in 52 people with OCD and 45 control participants. Gradients wer..

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University of Melbourne Researchers

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Keywords

Fmri
Brain Disorders
Mental Illness
52 Psychology
Mental Health
Neurosciences
Serious Mental Illness
Anxiety Disorders
Compulsivity
Gradients
5202 Biological Psychology
Longitudinal Changes