A multiscale vascular atlas of blood vessels supplying the urinary bladder of male and female mice

Abstract

The vascular supply of the urinary bladder is embedded within a highly dynamic environment that includes alternating cycles of regional compression or stretching during bladder filling, sustained continence, and voiding. These place unique demands on the vasculature to maintain tissue perfusion, fluid homeostasis, and immune surveillance. Understanding this vascular regulation is also highly relevant to defining mechanisms of organ reperfusion following pelvic surgery, pelvic venous insufficiency, and the impacts of diabetes and ischemia on urinary function. There is limited anatomical knowledge on the organization of this vascular network, so we aimed to determine if there are stereotypical..