Predicting long-term neurodevelopmental outcomes for children born very preterm: A systematic review

Abstract

Context: Children born very preterm (<32 weeks' gestation) have increased risk of neurodevelopmental difficulties compared with those born at term. While various neonatal exposures have been linked with later developmental challenges, identifying those at risk of difficulties later in childhood remains a challenge but is essential for targeting early intervention and counselling families. Objective: To systematically review and synthesise the evidence regarding early medical and environmental factors for neurodevelopmental impairment, cognitive, motor and behavioural outcomes for children born very preterm. Design: Ovid MEDLINE, Embase and PubMed were searched for articles between 1 January ..