Alcohol consumption and upper aerodigestive tract squamous cell carcinoma: Evidence from 28 prospective cohorts

E Ebrahimi; S Naudin; N Dimou; AL Mayén; M Wang; CC Abnet; A Åkesson; MJ Barnett; R Bellocco; A Berrington De Gonzalez; SE Bonn; C Chen; DC Christiani; TE Crane; AH Eliassen; JL Freudenheim; YT Gao; M Garcia-Closas; G Gierach; EL Giovannucci; IT Gram; N Håkansson; M Hirabayashi; T Hou; BZ Huang; JM Huerta; H Jayasekara; WP Koh; JV Lacey; YT Lagerros; E Loftfield; RJ Macinnis; S Mannisto; ME Martinez; ML McCullough; RL Milne; SC Moore; LA Mucci; ML Neuhouser; EA Platz; JN Poynter; AE Prizment; S Rees; K Robien; TE Rohan; N Sawada; VW Setiawan; MM Shams-White; XO Shu; R Sinha; MJ Stampfer; RZ Stolzenberg-Solomon; CA Thomson; CY Um; PA Van Den Brandt; K Visvanathan; R Wang; SS Wang; E White; KK White; WC Willet; A Wolk; Y Yano; SS Yaun; JM Yuan; W Zheng; E Riboli; SA Smith-Warner; P Brennan; P Ferrari

Journal article

Alcohol consumption and upper aerodigestive tract squamous cell carcinoma: Evidence from 28 prospective cohorts

E Ebrahimi, S Naudin, N Dimou, AL Mayén, M Wang, CC Abnet, A Åkesson, MJ Barnett, R Bellocco, A Berrington De Gonzalez, SE Bonn, C Chen, DC Christiani, TE Crane, AH Eliassen, JL Freudenheim, YT Gao, M Garcia-Closas, G Gierach, EL Giovannucci Show all

Journal of the National Cancer Institute | Published : 2025

DOI: 10.1093/jnci/djaf230

Abstract

Background This study aimed to investigate the association between alcohol consumption and squamous cell cancers of the upper aerodigestive tract (UADT), using data from 28 cohorts within the Pooling Project of Prospective Studies of Diet and Cancer (DCPP). Methods Individual-level data from 2 365 437 participants were pooled. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models to quantify the association between alcohol consumption (g/day) and UADT cancer risk, adjusting for potential confounders. Analyses were conducted by sex, smoking status, geographic region, and alcoholic beverages. Results Over a median follow-up of 15.5 years, 6903 UADT cancer cases..

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