Brain Changes After a Parenting Intervention in Adolescent Girls With Internalizing Symptoms: A Randomized Clinical Trial

Abstract

Importance Parenting interventions can improve adolescent internalizing outcomes, but their impact on neurobiological mechanisms remains unclear. Understanding neurobiological mechanisms underpinning the effects of parenting interventions is crucial for treatment refinement and development. Objective To investigate the effects of an emotion-focused parenting intervention on adolescent brain function and to determine whether intervention-induced brain changes are associated with behavioral and clinical outcomes. Design, Setting, and Participants This randomized clinical trial was conducted from April 2022 to June 2024. Participants were mother-daughter dyads, with daughters aged 10 to 12 year..