Oocyte quality in the era of AI: integration of morphology, metabolic activity and time-lapse imaging

Abstract

Significant advances have been made with regards to quantifying the viability of the preimplantation-stage human embryo, through the analysis of morphokinetics, quantification of biomarkers and trophectoderm biopsy to facilitate preimplantation genetic testing for aneuploidies (PGT). However, there is still limited capacity to determine the inherent potential of gametes. In particular, assessing the viability of an oocyte has been elusive, and the standard means of determining oocyte quality remains assessing its morphology. Unfortunately, except for grossly abnormal features, such as giant eggs, oocyte morphology is not strongly associated with clinical outcomes. With the rise of oocyte don..