Left atrioventricular ratio (LA:LV): using left ventricular size as the reference for identifying maladaptive left atrial remodelling

Abstract

Introduction Remodelling of the left atrium (LA) and left ventricle (LV) occurs in response to pathological and physiological stimuli, yet their inter-dependence is often overlooked in clinical practice. The left atrioventricular ratio (LA:LV)—the ratio of maximal LA end-systolic volume (LAESV) to LV end-diastolic volume (LVEDV)—may offer valuable context for distinguishing physiological from pathological cardiac remodelling. Methods and results This study evaluated LA:LV, assessed via echocardiography, and cardiorespiratory fitness assessed as peak oxygen uptake (VO2peak) in a multi-centre international cohort spanning the cardiorespiratory fitness spectrum. Exercise capacity in healthy par..