Anti-Parietal Cell Antibodies Show Differential Associations With Stomach Cancer by Site and Helicobacter pylori Status

Abstract

Background: Autoimmune gastritis poses a risk for stomach cancer. However, its role relative to Helicobacter pylori-associated gastritis is uncertain. We assessed whether the associations between anti-parietal cell antibody (APCA) seropositivity and the risk of stomach cancer and its anatomical subtypes were modified by H. pylori infection. Materials and Methods: A total of 244 incident gastric adenocarcinoma cases were identified from the Melbourne Collaborative Cohort Study (N = 41,513) and matched with 448 cancer-free controls using incidence density sampling with age as the time scale, matching on sex, year of birth, and country of birth. IgG antibodies against parietal cells and H. pylo..