Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

T Zhang; X Hua; C Mohindroo; X Wang; D Dutta; J Liu; S Katta; SA Li; J Wang; SO Antwi; AA Arslan; LE Beane Freeman; PM Bracci; F Canzian; M Du; S Gallinger; PJ Goodman; V Katzke; C Kooperberg; L Le Marchand; RE Neale; AV Patel; S Perdomo; XO Shu; K Visvanathan; SK Van Den Eeden; E White; W Zheng; D Albanes; G Andreotti; WR Bamlet; P Brennan; JE Buring; SJ Chanock; Y Chen; B Darst; P Ferrari; EL Giovannucci; M Goggins; C Haiman; M Hassan; EA Holly; RJ Hung; MR Jones; P Kraft; RC Kurtz; N Malats; SC Moore; K Ng; AL Oberg; I Orlow; U Peters; M Porta; KG Rabe; N Rothman; MJ Sánchez; HD Sesso; DT Silverman; MC Southey; CY Um; J Yarmolinsky; H Yu; C Yuan; J Zhong; BM Wolpin; HA Risch; LT Amundadottir; AP Klein; K Yu; H Zhang; RZ Stolzenberg-Solomon

Journal article

Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

T Zhang, X Hua, C Mohindroo, X Wang, D Dutta, J Liu, S Katta, SA Li, J Wang, SO Antwi, AA Arslan, LE Beane Freeman, PM Bracci, F Canzian, M Du, S Gallinger, PJ Goodman, V Katzke, C Kooperberg, L Le Marchand Show all

Journal of the National Cancer Institute | Published : 2026

DOI: 10.1093/jnci/djaf308

Abstract

Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. Methods We investigated associations of genetic susceptibility to type 2 diabetes (T2D), 8 T2D mechanistic clusters, type 1 diabetes (T1D), and maturity-onset diabetes of the young (MODY) with PDAC risk. We used genome-wide association study (GWAS) summary-level statistics for T2D (242 283 cases, 1 569 734 controls), T1D (18 942 cases, 501 638 controls), and PDAC (10 244 cases and 360 535 controls) in individuals of European ancestry. Results Two-sample Mendelian randomization (MR) using the R..

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