Thrombospondin-1 (THBS1) is dysregulated in preeclampsia

Abstract

Introduction: Preeclampsia involves endothelial dysfunction and impaired angiogenesis. Thrombospondin-1 (THBS1), a pro-thrombotic and anti-angiogenic glycoprotein, may contribute to preeclampsia pathogenesis. This study investigated the role of THBS1 in preeclampsia. Methods: THBS1 mRNA expression and protein levels were measured in placentas from early-onset preeclampsia (<34 weeks) and gestation-matched controls. Circulating THBS1 was assessed in early-onset preeclampsia and at 36 weeks’ gestation preceding diagnosis of preeclampsia at term. THBS1 was examined during human trophoblast stem cell (hTSC) differentiation into syncytiotrophoblast and extravillous trophoblast (EVT) and compared ..