Preferences for Subtyping Primary Aldosteronism: A Discrete Choice Experiment

Abstract

Context Primary aldosteronism (PA) affects 10% to 15% of individuals with hypertension and increases cardiovascular risk. Differentiating between unilateral and bilateral PA determines optimal treatment and typically requires adrenal vein sampling (AVS). Emerging subtyping methods include predictive algorithms and nuclear imaging. Objective This study explores hypertensive individuals' preferences for different PA subtyping strategies. Methods Two labeled discrete choice experiments (DCEs) evaluated preferences for subtyping methods based on test accuracy, waiting time, adverse effects, and out-of-pocket cost. Latent class conditional logit (LCL) modeling segmented participants by preference..