A systematic review and meta-analysis of the global epidemiology of carbapenem-resistant Escherichia coli

Abstract

Objectives Among drug-resistant strains, Escherichia coli is estimated to cause the largest number of deaths per year, globally. This study aimed to estimate the global prevalence of carbapenem-resistant E. coli through a systematic review and meta-analysis of the available literature. Methods Three databases, Embase, PubMed, and Scopus were screened for original research articles reporting the epidemiology of carbapenem-resistant E. coli between 2019 and 2023. Following data extraction, a meta-analysis was performed using the random effects model for overall prevalence and prevalence of key carbapenemase enzymes (NDM, OXA, IMP, VIM, and KPC). This systematic review was registered with PROSP..