Journal article
Improving actigraphy adherence among clinical trial participants with a real-time data-driven workflow
Alana O’Brien Del Campo, Daniel Sanchez, Meenakshi Chatterjee, Nikolay V Manyakov, Alex dos Santos, Suneel Mundle, Mark Wildgust, Mark Sapp, Rana Zia Ur Rehman, Neeraj Agarwal, Arun A Azad, Brian D Gonzalez, Alicia K Morgans, Ashita S Batavia
BMC Digital Health | Springer Science and Business Media LLC | Published : 2025
Abstract
Background & methodsHot flashes are a common side effect of androgen deprivation therapy in metastatic castration-sensitive prostate cancer (mCSPC). As part of the LIBERTAS trial evaluating an androgen-deprivation (ADT)-sparing maintenance regimen in mCSPC patients, novel exploratory endpoints of sleep quality and physical activity levels are being developed as objective and quantifiable proxies for hot flash burden. Actigraphy devices were given to study participants to capture data on sleep and physical activity. A workflow designed to increase participant wear of actigraphy devices was implemented three months into the study.ResultsAfter workflow deployment, the daily mean, variability, a..
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