Effectiveness of lifestyle interventions for preventing or managing the adverse cardiometabolic and other physical health effects of antipsychotic medications in children and adolescents: systematic review and meta-analysis

Abstract

Background An increasing number of children and adolescents are prescribed second-generation antipsychotic medications, which may lead to cardiometabolic or other physical health impairments. It is unknown whether lifestyle interventions can prevent or manage these adverse effects. Aims To evaluate the effectiveness of lifestyle interventions for preventing or managing cardiometabolic risks and other adverse physical health outcomes in this population. Method Four bibliographic databases were searched up to February 2024. Randomised controlled trials reporting a physical health outcome of children or adolescents (aged 6–17 years) taking antipsychotics and participating in a lifestyle interve..