Developing and testing bolt-on enhanced EQ-5D-5L for assessing Chinese patients with chronic obstructive pulmonary disease: a mixed-methods study protocol.

Abstract

INTRODUCTION: The EuroQol five dimensions questionnaire (EQ-5D) is widely used as a health-related quality of life (HRQoL) measure worldwide, but its sensitivity in detecting changes in health status among individuals with chronic obstructive pulmonary disease (COPD) remains suboptimal. Adding additional HRQoL dimensions (bolt-on items) to EQ-5D may enhance its sensitivity to specific diseases while preserving the original EQ-5D descriptive system. This study protocol documents the identification, development, selection and psychometric testing of respiratory-related bolt-on items for assessing COPD in China. METHODS AND ANALYSIS: We will conduct a content review of the COPD disease-specific..