Targeted Oxygen for Initial Resuscitation of Preterm Infants: The TORPIDO 30/60 Randomized Clinical Trial

JL Oei; A Kirby; J Travadi; P Davis; I Wright; A Ghadge; C Yeung; M Cruz; A Keech; W Hague; K Lui; M Vento; A Gordon; K De Waal; T Chaudhari; TSL Hong; S Morris; A Kushnir; D Bonney; M Tracy; K Kumar; AS Chhnia; VR Baral; P Muniyappa; FC Cheah; P Sarnadgouda; VS Rajadurai; U Balakrishnan; TP Oleti; V Aldecoa-Bilbao; ML Couce; CT Collados; RE Fernández; E Moliner; MD Ruiz Gonzalez; M Singhal; G Agrawal; J Singh; S Pal; S Nayya; R Arora; P Amboiram; J Simes; W Tarnow-Mordi; S Hunt; F Ali; L Ralston; J Michalowski; A Fucek; KS Rohini; R Dela Puerta; AH Barbero; K Martinello; L Prado; J Kong

Journal article

Targeted Oxygen for Initial Resuscitation of Preterm Infants: The TORPIDO 30/60 Randomized Clinical Trial

JL Oei, A Kirby, J Travadi, P Davis, I Wright, A Ghadge, C Yeung, M Cruz, A Keech, W Hague, K Lui, M Vento, A Gordon, K De Waal, T Chaudhari, TSL Hong, S Morris, A Kushnir, D Bonney, M Tracy Show all

JAMA | Published : 2026

DOI: 10.1001/jama.2025.23327

Abstract

Importance: The most effective initial fraction of inspired oxygen (Fio2) for resuscitating preterm newborns is unknown. Objective: To compare outcomes of newborns born at 23 to 28 weeks' gestation resuscitated with initial Fio2 of 0.6 vs 0.3. Design, Setting, and Participants: Randomized clinical trial conducted in 31 maternity hospitals in 6 countries. Consent by waiver was obtained in Australia, certain institutions in India, and Malaysia; prospective informed consent was obtained in certain institutions in India and all institutions in Singapore, Spain, and the US. Infants due at 23 to 28 weeks' gestation were randomized shortly before birth. Those with congenital abnormalities affecting..

View full abstract