Journal article
Cost-effectiveness analysis of hepatitis E screening and vaccination: targeting vulnerable populations in outbreak and sporadic settings in China.
Hanting Liu, Gang Chen, Yusheng Jie, Yong Jiang, Yao Huang, Xu Wang, Chun Hao, Jing Gu, Lei Zhang, Jinghua Li
Emerg Microbes Infect | Published : 2026
Open access
Abstract
This study evaluated the economic and health benefits of hepatitis E (HEV) screening and vaccination in both outbreak and sporadic settings in China. Decision-analytic Markov models were used to evaluate the population impact and cost-effectiveness of HEV screening and vaccination for people with chronic hepatitis B (CHB), older adults, pregnant women, and women of childbearing age. Simulations projected outcomes over six months for outbreak settings and lifetime horizons for sporadic settings. Incremental cost-effectiveness ratios (ICERs) were derived from a health system perspective with costs in 2023 US$. Robustness was examined through sensitivity analyses. Preventive universal scree..
View full abstractGrants
Awarded by Guangdong Basic and Applied Basic Research Foundation
Awarded by Fundamental Research Funds for the Central Universities, Sun Yat-sen University
Awarded by University of Macau Development Foundation Technology and Innovation Start-up Funding Scheme
Awarded by National Key R&D Program of China
Awarded by the Start-up Research Grant of the University of Macau
Awarded by The Ministry of Science and Technology of the People's Republic of China