3D-Printed Metal-Supported MOF-Heteropoly Acid Nanozyme for High-Performance Peroxidase-Mimic Activity and Ultra-Sensitive Glucose Detection

Abstract

The development of nanozymes combining high catalytic activity, mechanical robustness, and scalable fabrication is crucial for next-generation biomedical sensing. However, most current 3D-printed diagnostic platforms rely on polymeric substrates that suffer from limited reusability, weak mechanical strength, and poor long-term stability. Here, we report a sustainable and robust nanozyme system based on a 3D-printed Ti–Al─V alloy substrate, chosen for its excellent mechanical integrity, reusability, and intrinsically rough surface that promotes metal–organic framework growth. For the first time, an iron-based MOF (Fe-BTC) is directly grown on a 3D-printed Ti─Al─V substrates with in situ incor..