Global genomic surveillance of tigecycline resistance gene tet(X) in Salmonella enterica

Abstract

Objective The global transmission of plasmid-mediated tigecycline resistance gene tet (X) is a growing concern, yet its distribution in Salmonella remains poorly characterized. This study aimed to determine the prevalence and molecular features of tet (X) in Salmonella isolates from China and elucidate the global population structure and genomic surveillance framework. Methods A total of 865 Salmonella strains collected from diverse sources in China between 2019 and 2024 were screened for genetic analysis of tet (X), along with 89 tet (X)-positive Salmonella isolates from humans, animals, food, and the environment worldwide. Results One tet (X4)-positive S . 4,[5],12:i:- ST34 strain was reco..