Skin Cancers in Australian Liver Transplant Recipients: Risk Factors and Histology

Abstract

Background: Skin cancer is one of the most common comorbidities for liver transplant recipients (LTRs). Carcinogenesis is a multifaceted process: immunosuppression and personal risk factors such as smoking status, UV exposure, past history of skin cancer and family history of skin cancer can all play a significant role in determining the extent of skin cancer development. Objective: To undertake a large-scale retrospective case matched cohort study examining the effect of personal and transplant related risk factors in cutaneous carcinogenesis. Methods: A case–control study was performed of 114 LTRs who developed skin cancer who were compared to 288 age, sex, time since transplant and aetiol..