Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study

M Kirschner; B Hodzic-Santor; L Kennedy; JY Hansen; M Antoniades; I Nenadić; T Kircher; A Krug; T Meller; U Dannlowski; D Grotegerd; K Flinkenflügel; S Meinert; T Borgers; J Goltermann; T Hahn; J Böhnlein; EJ Leehr; C Barkhau; A Fornito; A Arnatkeviciute; MA Bellgrove; J Tiego; P DeRosse; M Green; Y Quidé; C Pantelis; RCK Chan; Y Wang; U Ettinger; M Debbané; M Derome; C Gaser; B Besteher; K Diederen; TJ Spencer; J Houenou; E Pomarol-Clotet; R Salvador; W Rössler; L Smigielski; V Kumari; P Premkumar; HRP Park; K Wiebels; I Jansen; J Gilleen; P Allen; JB Marsman; I Lebedeva; A Tomyshev; AK Fett; I Sommer; S Koops; P Grant; A Ferrari; B Wan; I Bègue; D Hernaus; M Jalbrzikowski; C Paquola; S Larivière; B Bernhardt; SL Valk; B Misic; TGM van Erp; JA Turner; PM Thompson; A Aleman; A Dagher; S Kaiser; G Modinos

Journal article

Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study

M Kirschner, B Hodzic-Santor, L Kennedy, JY Hansen, M Antoniades, I Nenadić, T Kircher, A Krug, T Meller, U Dannlowski, D Grotegerd, K Flinkenflügel, S Meinert, T Borgers, J Goltermann, T Hahn, J Böhnlein, EJ Leehr, C Barkhau, A Fornito Show all

Molecular Psychiatry | Published : 2026

DOI: 10.1038/s41380-026-03547-x

Abstract

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these schizotypy dimensions is lacking. Leveraging 3D brain MRI data from 2730 unmedicated healthy individuals, we identified neuroanatomical profiles of positive and negative schizotypy and systematically compared them with disorder-specific, microarchitectural, neurotransmitter-level, and connectome measures. Positive and negative schizotypy were associated with distinct cortical signatures, of predominantly thinner fro..

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