Peri-ictal magnetic resonance imaging abnormalities during status epilepticus in adults with idiopathic generalized epilepsy

Abstract

Objective: Peri-ictal abnormalities on diffusion-weighted magnetic resonance imaging (DWI-PMA) are well established in patients with status epilepticus (SE). SE occurs in approximately 4–9% of patients with idiopathic generalized epilepsy (IGE), and outcomes are generally more favorable than in SE due to other causes. We investigated whether the rate of DWI-PMA differs between SE associated with IGE and SE due to other etiologies. Methods: We performed a systematic review and individual patient meta-analysis of all studies published up to January 27th, 2025, reporting adult patients with non-anoxic SE and data on DWI-PMA. Results: A total of 4,227 studies were screened, of which 185 met elig..