Journal article
ABSTRACT NUMBER: ESOC2026LT15 LT15 - SAFETY AND EFFICACY OF RECOMBINANT HUMAN DNASE1 (DORNASE ALFA) AS AN ADJUVANT THROMBOLYTIC IN LARGE VESSEL ISCHAEMIC STROKE: THE EXTEND-IA DNASE CLINICAL TRIAL
Bruce Campbell, Vignan Yogendrakumar, Leonid Churilov, Hannah Johns, Chloe Mutimer, Valerian Altersberger, Gagan Jyoti Sharma, Philip Choi, Vincent Thijs, Timothy Kleinig
European Stroke Journal | Oxford University Press (OUP) | Published : 2026
Open access
Abstract
Abstract Background and aims Rates of early reperfusion with intravenous fibrinolytics in large vessel ischaemic stroke remain suboptimal. Dornase alfa (DNase1) has no role in physiological haemostasis but accelerates thrombolysis ex vivo through degradation of extracellular DNA in neutrophil extracellular traps, a key structural component of thrombus. We hypothesised that intravenous dornase, combined with standard care thrombolytic, would increase reperfusion at initial angiography pre-EVT in patients with ischaemic stroke due to large vessel occlusion. Methods ..
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