Clarifying risk-factor associations with quantitative breast tumor features: a pooled analysis of 24 studies.

Daniel Adams; Amber N Hurson; Thomas U Ahearn; Irene L Andrulis; Antonis C Antoniou; Päivi Auvinen; Anita Bane; Sabine Behrens; Amy Berrington de Gonzalez; Katarzyna Białkowska; Clara Bodelon; Manjeet K Bolla; Maria Borrero; Hermann Brenner; Ian W Brock; Annegien Broeks; Nicola J Camp; Melissa H Cessna; Stephen J Chanock; Georgia Chenevix-Trench; Ellen Copson; Fergus J Couch; Angela Cox; Simon S Cross; Peter Devilee; Alison M Dunning; Douglas F Easton; Diana M Eccles; Jonine D Figueroa; Gord Glendon; Anna González-Neira; Ute Hamann; Jaana M Hartikainen; Mikael Hartman; Bernadette AM Heemskerk-Gerritsen; Peh Joo Ho; James M Hodge; Bernd Holleczek; Antoinette Hollestelle; Maartje J Hooning; kConFab Investigators; SGBCC Investigators; Anna Jakubowska; Michael E Jones; Louise Jones; Brandt Jones; Audrey Jung; Rudolf Kaaks; Renske Keeman; Scott Lawrence; Jingmei Li; Jolanta Lissowska; Jan Lubiński; Arto Mannermaa; Mehdi Manoochehri; John WM Martens; Wilma E Mesker; Noor Muhammad; Anna Marie Mulligan; Nadia Obi; Janet E Olson; Ana Osorio; Penelope D Ottewell; Alpa V Patel; Guillermo Pita; Karolina Prajzendanc; Muhammad U Rashid; Kathryn J Ruddy; Fatemeh Safizadeh; Ben Schöttker; Petra Seibold; William J Tapper; Maria Tengström; Lauren R Teras; Heather Thorne; Mieke AM Timmermans; Rob AEM Tollenaar; Celine M Vachon; Qin Wang; Jelle Wesseling; Siddhartha Yadav; Xiaohong R Yang; M Pilar Zamora; Jenny Chang-Claude; Marjanka K Schmidt; Paul DP Pharoah; Mustapha Abubakar; Montserrat García-Closas

Journal article

Clarifying risk-factor associations with quantitative breast tumor features: a pooled analysis of 24 studies.

Daniel Adams, Amber N Hurson, Thomas U Ahearn, Irene L Andrulis, Antonis C Antoniou, Päivi Auvinen, Anita Bane, Sabine Behrens, Amy Berrington de Gonzalez, Katarzyna Białkowska, Clara Bodelon, Manjeet K Bolla, Maria Borrero, Hermann Brenner, Ian W Brock, Annegien Broeks, Nicola J Camp, Melissa H Cessna, Stephen J Chanock, Georgia Chenevix-Trench Show all

J Natl Cancer Inst | Published : 2026

DOI: 10.1093/jnci/djag244

Abstract

BACKGROUND: Breast cancer is etiologically heterogeneous, but which risk factors differ in their associations across tumor subtypes remains unclear. We conducted a large, pooled analysis to evaluate independent, dose-response associations between breast cancer risk factors and quantitative tumor features. METHODS: Analyses of 15,731 invasive breast cancers from 24 studies evaluated associations (p-trend) between reproductive and hormonal factors, body mass index (BMI), alcohol, smoking, and family history in relation to quantitative immunohistochemistry measures on tissue microarrays (ER, PR, HER2, KI67, TP53) and tumor grade. Analyses in a subset of 10 population-based studies estimated sub..

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