Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti-Inflammatory Functions

Abstract

Artificial nanozymes, defined as nanomaterials that mimic enzyme-like catalytic activity, emerge as adaptable tools for biomedical applications by uniting catalytic activity with structural stability and chemical versatility. Here, we introduce liquid gallium (Ga) as a catalytic center for nitric oxide (NO) generation and demonstrate its translation into a multifunctional coating. Ga nanoparticles were stabilized with tannic acid (TA) and embedded into a TA-zirconium (TA-Zr4+) metal-phenolic network (MPN), producing robust, substrate-independent films. Ga catalyzed the decomposition of S-nitrosothiols (RSNOs) through electron transfer, enabling NO generation from both model donors such as S-..