Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation in trophoblasts

M Kandel; L Bartho; NJ Hannan; P Cannon; TV Nguyen; A Nguyen; CN Murphy; GP Wong; S Tong; TJ Kaitu'u-Lino

Journal article

Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation in trophoblasts

M Kandel, L Bartho, NJ Hannan, P Cannon, TV Nguyen, A Nguyen, CN Murphy, GP Wong, S Tong, TJ Kaitu'u-Lino

Pregnancy Hypertension | Published : 2026

DOI: 10.1016/j.preghy.2026.101503

Open access

Abstract

Objectives: SIGLEC6, a human-specific transmembrane receptor, is highly expressed in placenta. SIGLEC6 is elevated in maternal circulation preceding preeclampsia and in women with preeclampsia, correlating with disease severity. This study aimed to investigate the regulatory mechanisms of placental SIGLEC6 and its involvement in processes associated with preeclampsia pathogenesis. Study design: To determine cell source, SIGLEC6 was measured in (cyto)trophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. We then assessed the impact of hypoxia (1% vs 8% Oxygen), inflammatory cytokines (Interleukin 6 (IL-6) or Tumour Necrosis Factor alpha (TNFα)), or Brefeldin A (impairs protein tra..

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