Unconventional guardians of the brain: MAIT cells as emerging players in glioblastoma immunity

Abstract

Glioblastomas (GBM) are an aggressive form of brain cancer with no curative treatment options. While T cell therapies have demonstrated substantial success in combatting blood cancers, their application for solid tumours, including GBM, is hampered by the immunosuppressive tumour microenvironment and scarcity of tumour antigen-specific targets. There is an urgent need to better understand the immune response to GBM to enable the development of new therapeutic approaches. Recently, a resident population of mucosal-associated invariant T (MAIT) cells in the brain has been described, which may perform critical immune surveillance functions. Recent research also suggests that MAIT cells play div..