Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis

Abstract

Objective: To determine the clinical consequences of acquiring Psuedomonas aeruginosa infection during early childhood in children with cystic fibrosis (CF). Design: Prospective, observational cohort study of 56 children with CF identified by newborn screening during 1990-92. Each child underwent an annual bronchial lavage during the first 2 to 3 years of life. Clinical outcome was determined at 7 years of age. Results: P aeruginosa infection was diagnosed in 24 (43%) cohort subjects. Four children died before 7 years of age, all of whom had been infected with a multi-resistant, mucoid strain of Paeruginosa (P = .04). In survivors, P aeruginosa infection was associated with significantly inc..