Journal article

The influence of extracellular matrix on the generation of vascularized, engineered, transplantable tissue

OCS Cassell, WA Morrison, A Messina, AJ Penington, EW Thompson, GW Stevens, JM Perera, HK Kleinman, JV Hurley, R Romeo, KR Knight, D Hunkeler (ed.), A Cherrington (ed.), A Prokop (ed.), R Rajotte (ed.)

BIOARTIFICIAL ORGANS III: TISSUE SOURCING, IMMUNOISOLATION, AND CLINICAL TRIALS | NEW YORK ACAD SCIENCES | Published : 2001

Abstract

In a recently described model for tissue engineering, an arteriovenous loop comprising the femoral artery and vein with interposed vein graft is fabricated in the groin of an adult male rat, placed inside a polycarbonate chamber, and incubated subcutaneously. New vascularized granulation tissue will generate on this loop for up to 12 weeks. In the study described in this paper three different extracellular matrices were investigated for their ability to accelerate the amount of tissue generated compared with a no-matrix control. Poly-D,L-lactic-co-glycolic acid (PLGA) produced the maximal weight of new tissue and vascularization and this peaked at two weeks, but regressed by four weeks. Matr..

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