Journal article

The contribution of reduced peak accrual of bone and age-related bone loss to osteoporosis at the spine and hip: Insights from the daughters of women with vertebral or hip fractures

A Tabensky, YB Duan, J Edmonds, E Seeman

JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2001

Abstract

The genetic hypothesis states that a daughter will resemble her mother by about 50% in a given trait because she shares, on average, half her genes. We used this trait resemblance in mothers and daughters to determine whether abnormalities in volumetric bone mineral density (vBMD) or bone size in women with fractures originate in growth or aging. vBMD and volume of the third lumbar vertebra and femoral neck were estimated using posteroanterior (PA) scanning by dual-energy X-ray absorptiometry (DXA). Vertebral volume was estimated as (scan area)(3/2) and femoral neck volume was pi* (width/2)(2)* height. vBMD was bone mineral content (BMC)/volume. The data were expressed as age-specific SD or ..

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University of Melbourne Researchers