Journal article

Anti-myelin associated glycoprotein antibodies: variability in patterns of IgM binding to peripheral nerve

G Lopate, AJ Kornberg, J Yue, R Choksi, A Pestronk

JOURNAL OF THE NEUROLOGICAL SCIENCES | ELSEVIER SCIENCE BV | Published : 2001

Abstract

We previously found that serums with anti-sulfatide antibodies have several different patterns of binding to neural tissue. In this study, we asked whether serums with anti-myelin associated glycoprotein (MAG) antibodies also have similar variations in patterns of tissue binding. We examined binding to peripheral nerve in 49 serums with IgM anti-MAG antibodies and 13 serums with IgM anti-sulfoglucuronyl paragloboside (SGPG) antibodies but no MAG binding. We correlated patterns of binding with titers of IgM binding to MAG and SGPG measured by ELISA methods. Our results show that IgM in most anti-MAG serums stained areas of non-compact myelin, including the periaxonal and outer myelin membrane..

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