Journal article

Angiotensin receptors: distribution, signalling and function

DT Dinh, AG Frauman, CI Johnston, ME Fabiani

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2001

Abstract

Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT(1) and AT(2). In addition, other angiotensin receptors have been identified which may recognize other angiotensin peptide fragments; however, until now only the AT(1) and AT(2) receptor have been cloned in animals or humans. Most of the well-described actions of Ang II, such as vasoconstriction, facilitation of sympathetic transmission, stimulation of aldosterone release and promotion of cellular growth are all mediated by the AT(1) receptor. Much less is known about the ..

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University of Melbourne Researchers