Journal article

Alzheimer's disease and AP toxicity: from top to bottom

DH Small, SS Mok, JC Bornstein

NATURE REVIEWS NEUROSCIENCE | NATURE PUBLISHING GROUP | Published : 2001

Abstract

Evidence implicating the β-amyloid protein (Aβ) in the pathogenesis of Alzheimer's disease has steadily accumulated. However, the mechanism by which Aβ causes dementia is unknown. Here we argue that a more integrated, top-down approach to brain function is needed to assess the role of Aβ in Alzheimer's disease, and that more attention should be paid to the effects of Aβ on synaptic function rather than on cell death. © 2001 Macmillan Magazines Ltd.