Journal article

Glycosaminoglycan synthesis in the separate layers of the chick sclera during myopic eye growth: Comparison with mammals

A Gentle, HT Truong, NA McBrien

CURRENT EYE RESEARCH | SWETS ZEITLINGER PUBLISHERS | Published : 2001

Abstract

PURPOSE: Studies in animal models of refractive development have shown that the development of and recovery from induced myopia is associated with visually-guided changes in scleral glycosaminoglycan synthesis. The present study sought to determine whether differential patterns of scleral glycosaminoglycan synthesis are present in the fibrous scleral layer of the chick during myopia development or recovery, as has previously been reported in the mammalian sclera. METHODS: Myopia was induced in young chicks by monocular deprivation of pattern vision over 5 days. Other animals underwent monocular deprivation, then had the occluder removed and were allowed 2 days of recovery. A group of age-mat..

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