Journal article

AUStralian Study of Titration to Effect Profile of Safety (AUS-STEPS): High-dose partial gabapentin (Neurontin) in partial seizures

R Beran, S Berkovic, A Black, G Danta, J Dunne, J Frasca, K Grainger, C Kilpatrick, R McKenzie, D McLaughlin, G Schapel, J Somerville

EPILEPSIA | WILEY | Published : 2001


PURPOSE: To evaluate the safety, tolerability, efficacy, and impact on quality of life of gabapentin (Neurontin; GBP) as adjunctive therapy in patients with refractory partial seizures. METHODS: AUS-STEPS was an open-label, multicenter, prospective study in patients experiencing partial seizures who were inadequately controlled with one to three concurrent antiepileptic drugs (AEDs). GBP treatment was titrated to a maximum of 4,800 mg/day, over a treatment period of 24 weeks, to achieve an efficacious and tolerable dosage. Efficacy was assessed by seizure-frequency data. Quality of life was evaluated by using the QOLIE-10 questionnaire, and safety was assessed by adverse-event reports and cl..

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