Journal article

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

AA Ruefli, MJ Ausserlechner, D Bernhard, VR Sutton, KM Tainton, R Kofler, MJ Smyth, RW Johnstone

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2001

DOI: 10.1073/pnas.191208598

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Keywords

Differentiation
Caspase 9
Caspase Activation
Humans
Caspase 3
Histone Deacetylase Inhibitors
Reactive Oxygen Species
Gene Expression
Caspase 8
Bh3 Interacting Domain Death Agonist Protein
Transcription, Genetic
Science & Technology
Vorinostat
Hydroxamic Acids
Fas
Cytochrome C Group
Proto-Oncogene Proteins C-Bcl-2
Multidisciplinary Sciences
Tumor Cells, Cultured
Apoptosis
Cytochrome-C Release
Science & Technology - Other Topics
Induced Apoptosis
Antineoplastic Agents
Caspase 10
P-Glycoprotein
Cancer-Therapy
Granzyme-B
Enzyme Inhibitors
Multidrug-Resistance
Leukemia-Cells
Caspases
Carrier Proteins