Journal article

c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer - Clinical and experimental findings

A Biroccio, B Benassi, I D'Agnano, C D'Angelo, S Buglioni, M Mottolese, A Ricciotti, G Citro, M Cosimelli, RG Ramsay, B Calabretta, G Zupi

AMERICAN JOURNAL OF PATHOLOGY | AMER SOC INVESTIGATIVE PATHOLOGY, INC | Published : 2001

Abstract

The aim of this study was twofold: to assess the relationship between c-Myb and Bcl-x expression and to evaluate the prognostic significance of their expression in colorectal carcinoma (CRC) patients. Analysis of tumors from 91 CRC patients for expression of c-Myb and Bcl-x revealed a significant relationship between these two proteins. Kaplan-Meier's analysis showed an increased risk of relapse and death in patients whose tumor specimens displayed high c-Myb levels and Bcl-x positivity. Similar results were also observed excluding Dukes' D patients. Molecular analysis using three c-Myb-overexpressing LoVo clones indicated that c-Myb overexpression was accompanied by up-regulation of Bcl-x(L..

View full abstract