Tolerance in baboon kidney transplantation with total lymphoid irradiation (TLI) and anti-CD3/CD4-Idarubicin conjugates

Abstract

Background. We previously reported the induction of transplantation tolerance by a modified wide field method of pretransplant total lymphoid irradiation (TLI), cumulative dose 800 cGy, given as 80 or 100 cGy fractions twice/week, in approximately one-third of chacma baboons receiving liver or kidney allografts (1-4) and in vervet monkeys receiving baboon kidney xenografts (5). In this study, the effects of the administration of brief courses of anti-CD3 or CD4-Idarubicin conjugates on the frequency and predictability of tolerance induction by TLI were examined. Methods. TLI was administered pretransplant in doses of 800, 600, or 400 cGy. The conjugates were administered either after transpl..