Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modification of amyloid deposits

Abstract

Indisputable evidence indicates that an inflammatory response is associated with neuron and neurite damage and the deposition of β‐Amyloid and neurofibrillary tangles in Alzheimer's disease. Nowhere is this more apparent than in Alzheimer's disease, where the loss of large hippocampal neurons and synaptic connections leads to progressive loss in memory and is associated with numerous inflammatory and oxidative changes. Similar inflammatory responses to protein accumulation are observed in other neurogenerative diseases. In this chapter we will review the acute phases response to inflammation, and the resultant oxidative environments that lead to the post‐translational modification of amyloid..