Stomach and Duodenal Ulcers: Diagnosis and Treatment

Abstract

Our understanding of gastroduodenal ulceration has improved phenomenally over the last two decades. The discovery by Warren and Marshall of Helicobacter pylori,[1] and its recognition as the causative organism in approximately 90% of duodenal ulcers has led to specific therapy for the condition and, consequently, very low relapse rates after successful treatment. NSAIDs, including low-dose aspirin, are responsible for most of the remaining duodenal ulcers and about half of all gastric ulcers. In a minority of patients, neither aetiological agent can be demonstrated. The proportion of H. pylori- and NSAID-negative ulcers is increasing in Western countries. Powerful acid-suppressant medication..