Fetal origins of adult disease?
R Morley, T Dwyer
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | WILEY-BLACKWELL | Published : 2001
1. Associations between lower birthweight and higher blood pressure, increased risk of type 2 diabetes and coronary heart disease (CHD) have been observed in a number of different populations worldwide. 2. The reason for this is still debated. Some believe that the observed associations can be explained on the basis of differences in postnatal growth, socioeconomic confounding or genetic factors. Two published studies of birthweight and CHD, with information on later size, suggest that both gestational and postnatal exposures are important. Associations between birthweight and blood pressure, seen in cohorts of twins treated as individuals, have generally remained when data are analysed with..View full abstract