Cognitive Outcome in Children with Myelomeningocele and Perinatal Hydrocephalus: A Longitudinal Perspective

Abstract

Myelomeningocele, a form of spina bifida where the vertebrae fail to fuse during foetal development, is often associated with sensory deficits, reduced motor function and hydrocephalus. These complications may interfere with the development of the central nervous system affecting myelination of axons and formation of synoptic connections, and development of cognitive skills, particularly where complications occur within the first twelve months of life. This paper examines the long-term cognitive outcome in nineteen children with myelomeningocele, who were shunted for hydrocephalus within the first year of life. In comparison to a healthy control group matched for age and gender, the clinical..