Does a Neurodevelopmental Lesion Involving the Hippocampus Explain Memory Dysfunction in Schizophrenia?

Abstract

Abstract: Schizophrenia is a mental disorder that has been associated with structural abnormalities of the medial temporal lobes and with impairments of memory function. The evidence for this association is weak. Many analyses have not investigated whether the impairment of memory is over and above the recognized impairments of global cognitive function, attention or working memory, all of which are disturbed in schizophrenia. Another difficulty evident in studies to date is that the construct of memory has rarely informed the selection of neuropsychological tests used. Lastly, an understanding of the normal development of cognitive functions has not guided interpretation of results. In this..