Vitamin E supplementation and macular degeneration: Randomised controlled trial

Abstract

Objective: To determine whether vitamin E supplementation influences the incidence or rate of progression of age related maculopathy (AMD). Design: Prospective randomised placebo controlled clinical trial. Setting: An urban study centre in a residential area supervised by university research staff. Participants: 1193 healthy volunteers aged between 55 and 80 years; 73% completed the trial on full protocol. Interventions: Vitamin E 500 IU or placebo daily for four years. Main outcome measures: Primary outcome: development of early age related macular degeneration in retinal photographs. Other measures included alternative definitions of age related macular degeneration, progression, changes i..