Journal article

Control of postganglionic neurone phenotype by the rat pineal gland

CR Anderson, SL Penkethman, AJ Bergner, RM McAllen, SM Murphy

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2002

Abstract

As neurones develop they are faced with choices as to which genes to express, to match their final phenotype to their role in the nervous system. A number of processes can guide these decisions. Within the autonomic and sensory nervous systems, there are a handful of examples that suggest that one mechanism that may match phenotype to function is the presence of target-derived differentiation factors. We tested whether the rat pineal gland controls the expression of a neuropeptide (neuropeptide Y) and a calcium-binding protein (calbindin) in sympathetic postganglionic neurones that innervate it. We first showed that the chemical phenotype of sympathetic neurones innervating the rat pineal in..

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