Journal article

Action potential afterdepolarization mediated by a Ca2 -activated cation conductance in myenteric AH neurons

F Vogalis, JR Harvey, RJ Lohman, JB Furness

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2002

Abstract

We investigated the nature of afterdepolarizing potentials in AH neurons from the guinea-pig duodenum using whole-cell patch-clamp recordings in intact myenteric ganglia. Afterdepolarizing potentials were minimally activated following action-potential firing under normal conditions, but after application of charybdotoxin (40 nM) or tetraethyl ammonium (TEA; 10-20 mM) to the bathing solution, prominent afterdepolarizing potentials followed action potentials. The whole-cell current underlying afterdepolarizing potentials (I(ADP)) in the presence of TEA (10-20 mM) reversed at -38 mV and was not voltage-dependent. Reduction of NaCl in the bathing (Krebs) solution to 58 mM shifted the reversal po..

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University of Melbourne Researchers