Alterations in vascular reactivity in single- and double-transgenic mice coexpressing human APP-C100 and mutant SOD1 genes

Abstract

Objective. To explore the mechanism underlying changes in microvascular reactivity in single- and double-transgenic mice. Methods. Peripheral vascular reactivity to the vasodilators, acetylcholine and sodium nitroprusside, on perfused microvasculature of the hind footpad was investigated using nontransgenic mice, single-transgenic mice expressing the human APP-C100 (TgC100.WT or TgC100.V717F) and double-transgenic mice coexpressing human APP-C100 and human SOD1 (G93A) genes. Results. Single TgC100 and double Tg mice C100/SOD1 (G93A) at 2-3 months old showed a statistical decrease of 28% in blood flux compared to nontransgenic control mice. In addition, vasodilative responsiveness was markedl..