Journal article

Public health aspects of genetic screening for hereditary haemochromatosis in Australia

DM Gertig, A Fletcher, JL Hopper

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH | WILEY | Published : 2002

Abstract

Hereditary haemochromatosis (HH) is an inherited disorder of iron absorption. It meets several of the key public health principles for population-based screening and is considered to be a test-case for public health genetics. However, there has been relatively little debate in the public health or wider community regarding the merits of population-based genetic screening for HH. Genetic susceptibility to HH occurs in about 1:200 people and although mortality is low (age-standardised rate 2.75/million), there are potentially serious clinical manifestations of iron overload. Regular venesection is a simple and effective treatment for early stage iron overload. DNA-based testing is available an..

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