Journal article

Synaptic distribution of ionotropic glutamate receptors in the inner plexiform layer of the primate retina

U Grunert, S Haverkamp, EL Fletcher, H Wassle

JOURNAL OF COMPARATIVE NEUROLOGY | WILEY | Published : 2002

Abstract

The distribution and synaptic clustering of glutamate receptors (GluRs) were studied in the inner plexiform layer (IPL) of the macaque monkey retina by using subunit specific antisera. A punctate immunofluorescence pattern was observed in the IPL for all subunits tested, and electron microscopy confirmed that the immunoreactive puncta represent clustering of receptors at sites postsynaptic to the bipolar cell ribbon synapses (dyads). Usually only one of the two postsynaptic processes at the dyads expressed a given subunit. Immunoreactive GluR2, GluR2/3, and GluR4 puncta were found at high density throughout the IPL and are probably expressed at every dyad. The GluR1 subunit was expressed at ..

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University of Melbourne Researchers